Predicting the winner of every MLB game on Friday, April 10th, 2026

Winning in MLB on a daily basis is one of the toughest challenges in sports. With 162 games, constant lineup changes, pitching matchups, and the unpredictable nature of baseball, picking winners isn’t about guessing—it’s about analyzing matchups and picking up on patterns. Every day presents a new slate, new opportunities, and new value. From analyzing starting pitchers and bullpen usage to identifying hot lineups and favorable matchups, success comes from staying consistent and trusting the process over the long haul. Here are today’s MLB predictions for final scores and the winners around the league.

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Pirates vs. Cubs

Aug 21, 2025; Chicago, Illinois, USA; Chicago Cubs starting pitcher Shota Imanaga (18) delivers a pitch against the Milwaukee Brewers during the first inning at Wrigley Field. Mandatory Credit: Kamil Krzaczynski-Imagn Images

Pitching Matchup: Mlodzinski vs. Imanaga
Score Prediction: 6-2
Winner: Cubs

Diamondbacks vs. Phillies

Pitching Matchup: Soroka vs. Luzardo
Score Prediction: 5-4
Winner: Phillies

Marlins vs. Tigers

Pitching Matchup: Paddack vs. Montero
Score Prediction: 4-2
Winner: Marlins

Angels vs. Reds

Pitching Matchup: Kochanowicz vs. Burns
Score Prediction: 6-3
Winner: Reds

Twins vs. Blue Jays

Apr 5, 2026; Minneapolis, Minnesota, USA; Minnesota Twins starting pitcher Simeon Woods Richardson (24) throws to the Tampa Bay Rays in the second inning at Target Field. Mandatory Credit: Bruce Kluckhohn-Imagn Images

Pitching Matchup: Woods Richardson vs. Corbin
Score Prediction: 5-2
Winner: Twins

Yankees vs. Rays

Pitching Matchup: Gil vs. Matz
Score Prediction: 4-3
Winner: Yankees

Athletics vs. Mets

Pitching Matchup: Ginn vs. Holmes
Score Prediction: 4-1
Winner: Mets

Guardians vs. Braves

Pitching Matchup: Cecconi vs. Elder
Score Prediction: 5-3
Winner: Braves

Giants vs. Orioles

Pitching Matchup: Roupp vs. Baz
Score Prediction: 3-2
Winner: Orioles

White Sox vs. Royals

Mar 30, 2026; Kansas City, Missouri, USA; Kansas City Royals starting pitcher Kris Bubic (50) delivers a pitch against the Minnesota Twins during the fourth inning at Kauffman Stadium. Mandatory Credit: Denny Medley-Imagn Images

Pitching Matchup: Martin vs. Bubic
Score Prediction: 5-4
Winner: Royals

Nationals vs. Brewers

Pitching Matchup: Irvin vs. Patrick
Score Prediction: 7-2
Winner: Brewers

Red Sox vs. Cardinals

Pitching Matchup: Early vs. May
Score Prediction: 6-4
Winner: Red Sox

Astros vs. Mariners

Apr 4, 2026; Anaheim, California, USA; Seattle Mariners starting pitcher Emerson Hancock (26) throws a pitch against the Los Angeles Angels during the first inning at Angel Stadium. Mandatory Credit: Jonathan Hui-Imagn Images

Pitching Matchup: Imai vs. Hancock
Score Prediction: 5-3
Winner: Mariners

Rockies vs. Padres

Pitching Matchup: Sugano vs. Buehler
Score Prediction: 8-4
Winner: Padres

Rangers vs. Dodgers

Pitching Matchup: Rocker vs. Glasnow
Score Prediction: 9-5
Winner: Dodgers

Conclusion:

At the end of the day, picking winners in Major League Baseball is a marathon, not a sprint. There will be bad beats, unexpected blowups, and nights where nothing goes according to plan; that’s the nature of baseball.

The key is staying disciplined, trusting the process, and finding edges over time. Stick with the matchups, follow the trends, and don’t overreact to one slate. We’ll be back with another breakdown, but for now, let’s see how today plays out.

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